HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethynylpyridine → N-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-(2-pyridin-2-yl-ethyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethynylpyridine | HCID 137268 | — |
| Reactant | (2R)-1-amino-2-cyclopropyl-propan-2-ol | HCID 51684102 | — |
| Reactant | 6-Chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester | HCID 86619575 | — |
| Product | N-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-(2-pyridin-2-yl-ethyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide | HCID 24797711 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 140, using 2-ethynyl-pyridine (CAN 1945-84-2), 6-chloro-5-(4-trifluoromethyl-phenyl)-nicotinic acid methyl ester, and (R)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials, LC at 215 nm; Rt 3.30: 98%, m/z (ES+): 470.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-66a6f00a8b314869a1fc4f7a825801c1 |
| Source note | uspto-grants-2012_05 |