HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → (R)-2-{[6-(4-Fluoro-phenyl)-5-pyrrolidin-1-yl-pyrazine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | (R)-methyl 2-amino-3-methylbutanoate | HCID 2305648 | — |
| Reactant | 5-Bromo-6-(4-fluoro-phenyl)-pyrazine-2-carboxylic acid methyl ester | HCID 86616957 | — |
| Product | (R)-2-{[6-(4-Fluoro-phenyl)-5-pyrrolidin-1-yl-pyrazine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester | HCID 24857430 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 146, using 5-bromo-6-(4-fluoro-phenyl)-pyrazine-2-carboxylic acid methyl ester, pyrrolidine and (R)-valine methyl ester as starting materials, LC at 215 nm; Rt 2.43: 100%, m/z (ES+): 401.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188093B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8d8de2cfb49e4326b2a03121c0f0134b |
| Source note | uspto-grants-2012_05 |