(1R,2R)-2-Aminocyclohexanol → HCID 67505152, compound

HRID 1929939Notes

Reaction equation

HRID 1929939 reaction equation
[Br:1][C:2]1[C:3]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]1[OH:25]>>[Br:1][C:2]1[C:3]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:18][C@@H:19]1[CH2:24][CH2:23][CH2:22][CH2:21][C@H:20]1[OH:25])=[O:9]

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 67504913HCID 67504913, compound

Product 1

HCID 67505152HCID 67505152, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31b, using 5-bromo-6-(5-hydroxy-pentyloxy)-nicotinic acid and (1R,2R)-2-amino-cyclohexanol as starting materials to give the product as white solid, MS (ISP): 403.4 (M+H+).

Workup

  1. customdescribed for the preparation of Example 31b

Sources & evidence

ORD record
ord-cce443d4dda7453bb3a5a4ba4aa48ea8
Source dataset
uspto-grants-2012_05
Patent number
US08188093B2

Reaction notes

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