N-Iodosuccinimide → HCID 57929914, compound

Participants

Reaction Steps

The 6-(2,4-difluorophenyl)-2,3-dihydroimidazo[2,1-b]oxazole (0.500 g, 2.25 mmol) was dissolved in DMF (6 mL) then NIS (0.533 g, 2.25 mmol) was added in one portion. The mixture was stirred at ambient temperature for about 15 min. The solvent was removed under reduced pressure then the residue was dissolved in DCM (6 mL) and purified by flash chromatography on silica gel using DCM/EtOAc (1:1) as an eluent. The desired fractions were combined and concentrated under reduced pressure to give a brown solid that was then triturated with water (10 mL). The solid was collected by filtration then dried under vacuum at about 70° C. for about 12 h to give the title compound (0.635 g, 81%): LC/MS (Table 1, Method h) Rt=1.39 min; MS m/z: 349 (M+H)+.

Provenance & Evidence