HCID 57929903, compound → HCID 57929880, compound

Participants

Reaction Steps

The 6-(1-(2-azidoethyl)-5-(2,4-difluorophenyl)-1H-pyrazol-4-yl)-3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazine (0.485 g, 1.19 mmol; prepared using General Procedure L.1 from 1-(2,4-difluorophenyl)-2-(3-isopropyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone (Preparation #K.1) with hydroxylethylhydrazine, General Procedure W with methanesulfonyl chloride, General Procedure X.1 with sodium azide) was dissolved in EtOH (20 mL) then platinum (IV) oxide (0.090 g, 0.40 mmol) was added. The mixture was hydrogenated at atmospheric pressure and ambient temperature for about 16 h then filtered through a pad of Celite®. The filtrate was concentrated under reduced pressure to give the title compound (0.447 g, 98%): LC/MS (Table 1, Method a) Rt=1.66 min; MS m/z: 384.3 (M+H)+.

Provenance & Evidence