Pyridine → 2-(6-(6-(2,4-Difluorophenyl)imidazo[2,1-b]oxazol-5-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-3-yl)propan-2-yl acetate

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Reaction Steps

2-(6-(6-(2,4-Difluorophenyl)imidazo[2,1-b]oxazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)propan-2-ol (0.125 g, 0.315 mmol, Example #37) was added to DCM (2 mL). Pyridine (0.077 mL, 0.95 mmol) and acetic anhydride (0.045 mL, 0.47 mmol) were added and the suspension was stirred at ambient temperature for about 15 min. Acetyl chloride (0.027 mL, 0.38 mmol) was added and the mixture was stirred at ambient temperature for about 30 min. DMF (1 mL), pyridine (0.077 mL, 0.95 mmol) and acetyl chloride (0.027 mL, 0.38 mmol) were added then the mixture was heated at about 85° C. for about 90 min. The mixture was cooled to ambient temperature, concentrated under reduced pressure then purified by RP-HPLC (Table 1, Method f). Concentration under reduced pressure resulted in a precipitate that was collected by filtration and dried to give the title compound (0.075 g, 54%): LC/MS (Table 1, Method g) Rt=1.96 min; MS m/z: 438.9 (M+H)+.

Provenance & Evidence