Isobutyraldehyde → HCID 57929944, compound

Participants

Reaction Steps

To a flask was added 6-(2,4-difluorophenyl)-5-(2-hydrazinylpyrimidin-5-yl)imidazo[2,1-b]oxazole (0.120 g, 0.366 mmol) and DCM (8 mL). Isobutyraldehyde (0.026 g, 0.366 mmol) and HOAc (0.000021 mL, 0.000366 mmol) were added. The reaction mixture was stirred at ambient temperature for about 2 h. Then iodobenzene diacetate (0.124 g, 0.384 mmol) was added. The reaction mixture was stirred at ambient temperature for about 2 h. The crude material was purified by silica gel flash chromatography using a gradient of 0-20% MeOH in DCM to give the title compound (0.085 g, 61%): LC/MS (Table 1, Method a) Rt=2.62 min; MS m/z: 381.2 (M+H)+.

Provenance & Evidence