反应详情

To a solution of berberine hydrochloride (3,718 g, 10 mmol) in pyridine (30 mL) was added portionwise sodium borohydride (450 mg, 12 mmol) and the mixture was stirred at room temperature for 30 min. More sodium borohydride (380 mg, 10 mmol) was added and stirring was continued for 1 h. The reduction was monitored by TLC (DCM-ethyl acetate-methanol 4:4:2). The mixture was poured onto ice water. The precipitate was filtered, the residue washed with water and then dried under vacuum over calcium chloride to give 2.860 g of title compound in about 85 % yield.

1. stirringstirring
2. waitwas continued for 1 h
3. additionThe mixture was poured onto ice water
4. filtrationThe precipitate was filtered
5. washthe residue washed with water
6. dry with materialdried under vacuum over calcium chloride