Hydrochloric Acid → 2-(4'-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorobiphenyl-4-yl)acetic acid

Participants

Reaction Conditions

Reaction Steps

Powdered potassium hydroxide (45.2 mg, 0.81 mmol) was added in one portion to methyl 2-(4′-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorobiphenyl-4-yl)acetate (Intermediate 1-1; 110 mg, 0.27 mmol) in tert-butanol (10 mL) at 45° C. The resulting solution was stirred at 45° C. for 15 minutes, a thick white suspension slowly formed. 2M HCl (2 mL) was added and the mixture was evaporated to remove the organic solvent. The suspension was collected by filtration, washed with water (5 mL) and dried under vacuum to afford 2-(4′-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)-2-chlorobiphenyl-4-yl)acetic acid (82 mg, 77%) as a white solid.

Provenance & Evidence