HCID 57652497, compound → SAR407899

HRID 1930203Notes

Reaction equation

HRID 1930203 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21]([O:25]CC2C=CC=CC=2)=[N:20][CH:19]=[CH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)C>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:22](=[CH:23][CH:24]=2)[C:21](=[O:25])[NH:20][CH:19]=[CH:18]3)[CH2:12][CH2:13]1

Participants

3

Reactant 1

HCID 57652497HCID 57652497, compound

Product 1

HCID 15604510SAR407899

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Coumpound (11) was dissolved in ethanol/2 N HCl (1:1) and stirred at room temperature until complete conversion was achieved. The solvent was removed i. vac. and the residue was purified by preparative HPLC. The resulting trifluoroacetate was dissolved in 2 N HCl and lyophilized. After another lyophilization from water, 850 mg of the title compound could be obtained as HCl salt. Rt=0.75 min (Method B). Detected mass: 245.1 (M+H+).

Workup

  1. customThe solvent was removed i
  2. customand the residue was purified by preparative HPLC
  3. dissolutionThe resulting trifluoroacetate was dissolved in 2 N HCl

Sources & evidence

ORD record
ord-9db8547baac6422cb80288ed32dbb560
Source dataset
uspto-grants-2012_05
Patent number
US08188117B2

Reaction notes

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