化工社化工社 化学情報印刷レポート · 研究参考用
Cesium carbonate → 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 反応物 | 6-Fluoroisoquinolin-1(2H)-one | HCID 45090802 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one | HCID 59818260 | 93.7% |
反応手順
169 μL of p-methoxybenzylchloride (1.24 mmol, 1.1 eq) were added to a suspension of 200 mg of 6-fluoro-isoquinolinone (13) (1.13 mmol) and 368 mg of Cs2CO3 (1.36 mmol, 1.2 eq) in 3 mL of DMF. The mixture was stirred for 2 h and then poured on ice. The precipitate was filtered, washed with water and dried to yield 300 mg of the title compound. LCMS Method B, retention time 1.76 min, detected mass 284.14 [M+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08188117B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-69a7ed0ca77341ce88ef0eeaab37f2c0 |
| 出典メモ | uspto-grants-2012_05 |