HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(4-Bromo-3-fluorophenyl)prop-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 3-(4-bromo-3-fluorophenyl)prop-2-enoate | HCID 67313932 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Bromo-3-fluorophenyl)prop-2-enoic acid | HCID 67456640 | 84.6% |
Reaction Steps
10.5 g (38.6 mmol) of 3-(4-bromo-3-fluoro-phenyl)-acrylic acid ethyl ester were dissolved in 100 mL of methanol and stirred overnight with 97 mL of aqueous 1 M sodium hydroxide solution. After removal of the methanol in vacuo the residue was acidified with concentrated hydrochloric acid. The precipitate was isolated by suction and dried in vacuo at 50° C. furnishing 8.0 g of 3-(4-bromo-3-fluoro-phenyl)-acrylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188117B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-ead58592dabe476faca4a17b043d5ef5 |
| Source note | uspto-grants-2012_05 |