HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one → 7-Phenyl-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one | HCID 57652347 | — |
| Reactant | 4-[2-(4-Methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57652576 | — |
| Product | 7-Phenyl-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one | HCID 57652404 | — |
Reaction Steps
4-[2-(4-Methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (316) was deprotected following the method described for 7-bromo-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one (17). Similar work up delivers the title compound as HCl-salt. Rt=1.05 min (Method B). Detected mass: 321.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188117B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e1216d0a45004e6fb736eb1790c264c5 |
| Source note | uspto-grants-2012_05 |