HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-[7-Ethyl-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | 4-[2-(4-Methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57652576 | — |
| Reactant | 7-Ethyl-6-fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1(2H)-one | HCID 59818258 | — |
| Product | 4-[7-Ethyl-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57652598 | — |
Reaction Steps
The title compound was synthesized following the method described for 4-[2-(4-methoxy-benzyl)-1-oxo-7-phenyl-1,2-dihydro-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (316), starting from 7-ethyl-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (318) and 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester. Rt=1.91 min (Method C). Detected mass: 493.6 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188117B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-558a788bce204a7fb821588562297d94 |
| Source note | uspto-grants-2012_05 |