Methanesulfonyl chloride → N-[(4-Methoxyphenyl)Methyl]Methanesulfonamide

Participants

Reaction Steps

To a solution of (4-methoxyphenyl)methanamine (1.317 g, 9.60 mmol) in CH2Cl2 (10 mL) was added methanesulfonyl chloride (0.34 mL, 4.36 mmol) dropwise. The mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with 50 mL CH2Cl2 washed with 1N H3PO4, 10% NaCl, dried over anhydrousmgSO4, filtered and concentrated in vacuo to give the title compound as a white solid (0.84 g, 89%).

Provenance & Evidence