Pentanenitrile, 4,4-dimethyl-3-oxo- → 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetamide

HRID 1930322Notes

Reaction equation

HRID 1930322 reaction equation
[NH2:1][C:2](=[O:12])[CH2:3][C:4]1[CH:5]=[C:6]([NH:10][NH2:11])[CH:7]=[CH:8][CH:9]=1.[CH3:13][C:14]([CH3:21])([CH3:20])[C:15](=O)[CH2:16][C:17]#[N:18]>>[NH2:18][C:17]1[N:10]([C:6]2[CH:5]=[C:4]([CH2:3][C:2]([NH2:1])=[O:12])[CH:9]=[CH:8][CH:7]=2)[N:11]=[C:15]([C:14]([CH3:21])([CH3:20])[CH3:13])[CH:16]=1

Participants

3

Reactant 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 21867344HCID 21867344, compound

Product 1

HCID 218673072-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetamide

Procedure

3-(2-amino-2-oxoethyl)phenyl hydrazine and 4,4-dimethyl-3-oxopentanenitrile were combined according to literature procedures to yield 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetamide. See WO 2006/071940.

Sources & evidence

ORD record
ord-a281b3a8bb7743028969f87eebfdfb87
Source dataset
uspto-grants-2012_05
Patent number
US08188113B2

Reaction notes

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