HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropenyl chloroformate → Prop-1-en-2-yl 3-(trifluoromethyl)isoxazol-5-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropenyl chloroformate | HCID 93846 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | 3-(Trifluoromethyl)-1,2-oxazol-5-amine | HCID 13913996 | — |
| Product | Prop-1-en-2-yl 3-(trifluoromethyl)isoxazol-5-ylcarbamate | HCID 69299521 | 38.2% |
Reaction Steps
Using general method G, 3-(trifluoromethyl)isoxazol-5-amine (1.38 g, 9.1 mmol) and isopropenyl chloroformate (1.1 g, 9.1 mmol) in presence of LiHMDS (1.0M, 18 mL, 18.2 mmol) were combined to afford prop-1-en-2-yl 3-(trifluoromethyl)isoxazol-5-ylcarbamate (0.82 g, 38% yield).). 1H NMR (400 MHz, DMSO-d6): δ 12.3 (s, 1H), 6.48 (s, 1H), 4.83 (m, 1H), 4.80 (m, 1H), 1.93 (s, 3H); MS (ESI) m/z: 237.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6e1fece7dd114a8c8d56403bcd7b0ee2 |
| Source note | uspto-grants-2012_05 |