Lithium hydroxide, monohydrate → HCID 69039163, compound

Participants

Reaction Steps

Using a procedure analogous to Example B32, methyl 2-tert-butyl-4-(1-methyl-1 H-indol-5-yl)pyrimidine-5-carboxylate (898 mg, 2.78 mmol) and lithium hydroxide hydrate (466 mg, 11.11 mmol) were combined to give 2-tert-butyl-4-(1-methyl-1 H-indol-5-yl)pyrimidine-5-carboxylic acid (833 mg, 97% yield). 1H NMR (300 MHz, DMSO-d6): δ 1.39 (s, 9 H), 3.82 (s, 3H), 6.54 (s, 1 H), 7.40 (s, 1 H), 7.52 (m, 2 H), 7.94 (s, 1 H), 8.91 (s, 1 H), 12.70 (s, 1 H); MS (ESI) m/z: 310.0(M+H+).

Provenance & Evidence