Ethanol → HCID 69034876, compound

Participants

Reaction Steps

A solution of 2-(5-amino-1-phenyl-1 H-pyrazol-3-yl)-2-methyl-propionitrile (1.0 g, 7.4 mmol) and aq NaOH (2 M, 11 mL, 22 mmol) in EtOH (10 mL) was heated to 70° C. for 12 h. The reaction mixture was partitioned between ether and water and the aqueous solution was acidified with HCl to pH 4-5. The aqueous was extracted with EtOAc (3×50 mL) and the extracts were concentrated in vacuo to give crude 2-(5-amino-1-phenyl-1 H-pyrazol-3-yl)-2-methylpropanoic acid (0.7 g, 39% yield) which was used without further purification.

Provenance & Evidence