HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinylboronic acid → Ethyl 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinylboronic acid | HCID 2734378 | — |
| Reactant | Ethyl 2-(tert-butyl)-4-chloropyrimidine-5-carboxylate | HCID 24903912 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | Ethyl 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylate | HCID 68983241 | 28.3% |
Reaction Steps
Using a procedure analogous to Example B41, ethyl 2-tert-butyl-4-chloropyrimidine-5-carboxylate from Example B40 (0.30 g, 1.24 mmol) and pyridin-3-ylboronic acid (1.8 g, 1.48 mmol) in presence of tetrakis(triphenylphosphine)palladium(0) (71 mg, 0.062 mmol) were combined to afford ethyl 2-tert-butyl-4-(pyridin-3-yl)pyrimidine-5-carboxylate (0.10 g, 28% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-e6f128ded30848f2955d736ab7faf0ac |
| Source note | uspto-grants-2012_05 |