HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Tert-butyl-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-(tert-butyl)-4-chloropyrimidine-5-carboxylate | HCID 24903912 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-Tert-butyl-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylic acid | HCID 69297514 | 32% |
Reaction Steps
Using a procedure analogous to Example B40, ethyl 2-tert-butyl-4-chloropyrimidine-5-carboxylate from Example B40 (0.30 g, 1.24 mmol) and 1-methylpiperazine (0.62 g, 6.18 mmol) in presence of NMP (catalytic amount) were combined to afford 2-tert-butyl-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylic acid (0.11 g, 32% yield). MS (ESI) m/z: 279.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188113B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-24cd7feb2990438a8b2166aecfb95349 |
| Source note | uspto-grants-2012_05 |