反应详情

A mixture of (Z)-2-benzyloxycarbonylamino-3-(cis-3-methyl-cyclobutyl)-acrylic acid methyl ester (prepared in Example 214, 275 mg, 0.91 mmol), methanol (10 mL) and 10% palladium on activated carbon (50 mg) was placed in a Parr shaker bottle. It was then placed on the Parr hydrogenator apparatus and charged with hydrogen to 40 psi and shaken for 1 h. After such time, the catalyst was filtered through a plug of celite and the filterate was concentrated in vacuo to afford 2-amino-3-(trans-3-methyl-cyclobutyl)-propionic acid methyl ester (134 mg, 86%) as a pale yellow oil.

1. filtrationAfter such time, the catalyst was filtered through a plug of celite
2. concentrationthe filterate was concentrated in vacuo