反应详情

温度

85 °C

2-(4-Fluoro-2-methyl-5-nitrophenyl)acetic acid (18.43 g, 86.5 mmol, 1.00 eq) and cone. H2SO4 (4.00 ml) were combined in EtOH (300 ml) and stirred with heating at 85° C. After 2.5 h, the completed reaction was cooled to RT and concentrated as completely as possible. The residue was dissolved in MTBE (250 ml) and washed with H2O (2×) and brine (2×), dried (MgSO4), filtered and evaporated to afford ethyl 2-(4-fluoro-2-methyl-5-nitrophenyl)acetate (16.79 g, 81% yield) as a dark orange oil which was used as is in the next reaction. MS (ESI) m/z: 242.0 (M+H)+.

1. customthe completed reaction
2. temperaturewas cooled to RT
3. concentrationconcentrated as completely as possible
4. dissolutionThe residue was dissolved in MTBE (250 ml)
5. washwashed with H2O (2×) and brine (2×)
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customevaporated