Methylamine → HCID 69297554, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(3-tert-butylisoxazol-5-yl)-3-(2-fluoro-4-methyl-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (1.70 g, 3.426 mmol) and methylamine (2 ml, 4 mmol, 2.0M in THF) were combined to provide 1-(3-tert-butylisoxazol-5-yl)-3-(2-fluoro-4-methyl-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (92 mg, 42% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.28 (brs, 1H), 8.67 (brs, 1H), 8.61 (s, 1H), 7.89 (d, J=9 Hz, 1H), 7.82 (brs, 1H), 7.68 (s, 1H), 7.17 (d, J=12 Hz, 1H), 6.00 (s, 1H), 3.58 (s, 3H), 2.90 (d, J=5 Hz, 3H), 2.08 (s, 3H), 1.21 (s, 9H); MS (ESI) m/z: 480.2(M+H+).

Provenance & Evidence