Methylamine → HCID 69040265, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(1-tert-butyl-1H-pyrazol-4-yl)-3-(2-fluoro-5-(8-isopropyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (0.065 g, 0.13 mmol) and 2 M methylamine in THF (1 mL) were combined to afford 1-(1-tert-butyl-1H-pyrazol-4-yl)-3-(2-fluoro-5-(8-isopropyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea as white solid (39 mg, 62%). 1H NMR (400 MHz, DMSO-d6): δ 8.68 (s, 1H), 8.62 (s, 1H), 8.48 (d, J=2.0 Hz, 1H), 8.34 (d, J=7.6 Hz, 1H), 7.80 (s, 1H), 7.79 (s, 1H), 7.78-7.74 (m, 1H), 7.38 (s, 1H), 7.22-7.20 (m, 2H), 5.77-5.74 (m, 1H), 2.89 (d, J=4.4 Hz, 3H), 1.59-1.55 (m, 6H), 1.46 (m, 9H); MS (ESI) m/z: 493.2 (M+H+).

Provenance & Evidence