Methylamine → HCID 69035165, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(2,4-difluoro-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-(trifluoromethyl)isoxazol-5-yl)urea (65 mg, 0.130 mmol) and 2.0N methylamine in THF (0.63 mL, 1.3 mmol) were combined to afford 1-(2,4-difluoro-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-(trifluoromethyl)isoxazol-5-yl)urea (8 mg, 13% yield). MS (ESI) m/z: 496.0 (M+H+).

Provenance & Evidence