Methylamine → HCID 69297876, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(4-chloro-2-fluoro-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-(trifluoromethyl)isoxazol-5-yl)urea (75 mg, 0.140 mmol) and 2.0 N methylamine in THF (0.71 mL) were combined to afford 1-(4-chloro-2-fluoro-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-(trifluoromethyl)isoxazol-5-yl)urea (15 mg, 21% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.89 (s, 3H), 3.51-3.58 (m, 3H), 6.48 (s, 1H), 7.61 (d, J=11 Hz, 1H), 7.77 (s, 1H), 7.88-7.90 (m, 1H), 8.04 (d, J=9.5 Hz, 1H), 8.61-8.69 (m, 1H), 9.01 (s, 1H), 11.0 (s, 1H); MS (ESI) m/z: 512.0 (M+H+).

Provenance & Evidence