Methylamine tetrahydrofuran → HCID 69296308, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(2-fluoro-4-methyl-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-isopropylisoxazol-5-yl)urea (0.203 g, 0.421 mmol, 1.00 eq) and 2.00M MeNH2/THF (2.10 ml, 4.21 mmol, 10.00 eq,) were combined to afford 1-(2-fluoro-4-methyl-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(3-isopropylisoxazol-5-yl)urea (41 mg, 21% yield) as a pale yellow powder. 1H NMR (400 MHz, DMSO-d6) δ 10.28 (s, 1H), 8.67 (brs, 1H), 8.60 (s, 1H), 7.88 (d, J=8.0 Hz, 1H), 7.81 (brq, J=4.0 Hz, 1H), 7.67 9s, 1H), 7.17 (d, J=12.8 Hz, 1H), 5.96 (s, 1H), 3.59 (s, 3H), 2.90 (d, J=4.8 Hz, 3H), 2.89 (septet, J=7.2 Hz, 1H), 2.08 (s, 3H), 1.16 (d, J=7.2 Hz, 6H); MS (ESI) m/z: 466.0 (M+H+).

Provenance & Evidence