Methylamine → HCID 69094684, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(1-tert-butyl-1H-pyrazol-4-yl)-3-(2,4-difluoro-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (80 mg, 0.160 mmol) and 2.00N methylamine in THF (0.9 mL, 1.80 mmol) were combined to afford 1-(1-tert-butyl-1H-pyrazol-4-yl)-3-(2,4-difluoro-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (31 mg, 36% yield). 1H NMR (300 MHz, DMSO-d6) δ 1.53 (s, 9H), 2.90 (s, 3H), 3.52-3.59 (m, 3H), 7.31-7.38 (m, 2H), 7.78-7.90 (m, 3H), 8.12-8.16 (m, 1H), 8.48 (s, 1H), 8.63-8.70 (m, 1H), 8.65 (s, 1H); MS (ESI) m/z: 483.3 (M+H+).

Provenance & Evidence