Methylamine tetrahydrofuran → HCID 69296299, compound

Participants

Reaction Steps

Following a procedure analogous to Example A1, 1-(2-fluoro-4-methyl-5-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(5-isopropylisoxazol-3-yl)urea (0.0635 g, 0.13 mmol) and 2.0M MeNH2/THF (0.66 ml, 1.3 mmol) were combined to afford 1-(2-fluoro-4-methyl-5-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(5-isopropylisoxazol-3-yl)urea (38 mg, 62% yield) as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6): δ 9.77 (s, 1H), 8.75 (brs, 1H), 8.60 (s, 1H), 7.92 (d, J=8.4 Hz, 1H), 7.80 (brq, J=4.4 Hz, 1H), 7.68 (s, 1H), 7.36 (d, J=12.4 Hz, 1H), 6.45 (s, 1H), 3.60 (s, 3H), 2.99 (septet, J=6.8 Hz, 1H), 2.90 (brd, J=4.4 Hz, 3H), 2.07 (s, 3H), 1.20 (d, J=6.8 Hz, 6H); MS (ESI) m/z: 466.2 (M+H+).

Provenance & Evidence