Methylamine → HCID 69297949, compound

Participants

Reaction Steps

Using a procedure analogous to Example A1, 1-(3-tert-butylisoxazol-5-yl)-3-(4-methyl-3-(8-methyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (56 mg, 0.117 mmol) and 2.0N methylamine in THF (0.71 mL, 1.421 mmol) were combined to afford 1-(3-tert-butylisoxazol-5-yl)-3-(4-methyl-3-(8-methyl-2-(methylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (29 mg, 44% yield). 1H NMR (300 MHz, DMSO-d6), δ 1.46 (s, 9H), 2.04 (s, 3H), 2.89 (s, 3H), 3.52-3.60 (m, 3H), 5.74 (s, 1H), 7.08-7.10 (m, 1H), 7.22-7.25 (m, 1H), 7.33-7.36 (m, 2H), 7.65 (s, 1H), 7.78 (s, 1H), 7.68-7.82 (m, 1H), 8.25 (s, 1H), 8.53 (s, 1H), 8.60-8.65 (m, 1H); MS (ESI) m/z: 462.3 (M+H+).

Provenance & Evidence