HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dibromopyridine → 4-(5-bromopyridin-2-yl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | 4-Formylphenylboronic Acid | HCID 591073 | — |
| Product | 4-(5-bromopyridin-2-yl)benzaldehyde | HCID 11849714 | 71% |
Reaction Steps
The same procedure described for 1 was used by employing 2,5-dibromopyridine (1 equiv.) and 4-formylphenyl boronic acid (1 equiv.). Yield 71%, mp 120-121° C. 1H NMR (DMSO-d6); δ 7.97 (d, J=8.4 Hz, 2H), 8.04 (d, J=8.7 Hz, 1H), 8.16 (dd, J=2.4, 8.7 Hz, 1H), 8.26 (d, J=8.4 Hz, 2H), 8.80 (d, J=2.4 Hz, 1H), 10.08 (s, 1H). MS (ESI) m/e (rel. int.): 262 (M+, 100), 232 (30), 153 (55). Anal. Calc. for C12H8BrNO: C %, 54.99; H %, 3.08. Found C %, 54.75; H %, 3.14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188121B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-88ed7d5442f14d06a73188cbacf4429e |
| Source note | uspto-grants-2012_05 |