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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1930502Generated: November 2, 2026

(4-Bromophenyl)boronic acid → HCID 58477999, compound

https://huagongshe.com/reaction/1930502

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Bromophenyl)boronic acidHCID 79599—
Reactant6-Bromopyridine-3-carbonitrileHCID 5005718—
Reactant5-(4-Bromophenyl)picolinonitrileHCID 58478022—
ProductHCID 58477999HCID 5847799978%

Reaction Steps

The same procedure described for 5-(4′-bromophenyl)-2-pyridinecarbonitrile was used by employing 2-bromo-5-cyanopyridine and 4-bromophenylboronic acid to furnish 81 in 78% yield; mp 157-159° C. 1H NMR (DMSO-d6): δ 7.74 (d, J=8.8 Hz, 2H), 8.12 (d, J=8.8 Hz, 2H), 8.22 (d, J=8.4 Hz, 1H), 8.40 (dd, J=2.4, 8.4 Hz, 1H), 9.09 (d, J=2.4 Hz, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08188121B2
Source datasetuspto-grants-2012_05
ORD IDord-47b43091766046a0b6c2f56028d41d0d
Source noteuspto-grants-2012_05