(4-Bromophenyl)boronic acid → HCID 67248034, compound

HRID 1930503Notes

Reaction equation

HRID 1930503 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=C[C:11]([C:14]#[N:15])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.BrC1C=[N:19]C(C#N)=NC=1.BrC1C=CC(B(O)O)=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[N:12][C:11]([C:14]#[N:15])=[N:19][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 79599(4-Bromophenyl)boronic acidHCID 6865465-Bromopyrimidine-2-carbonitrileHCID 58478022HCID 58478022, compound

Product 1

HCID 67248034HCID 67248034, compoundYield 58%

Procedure

The same procedure described for 5-(4′-bromophenyl)-2-pyridinecarbonitrile was used by employing 5-bromo-2-cyanopyrimidine and 4-bromophenylboronic acid to furnish 84 in 58% yield; mp 202-204° C. 1H NMR (DMSO-d6): δ 7.79 (d, J=8.4 Hz, 2H), 7.88 (d, J=8.4 Hz, 1H), 9.39 (s, 2H).

Sources & evidence

ORD record
ord-b29942c817994b299c56bea5a4bb22f0
Source dataset
uspto-grants-2012_05
Patent number
US08188121B2

Reaction notes

Loading…