Hydrochloric Acid → HCID 46200197, compound

Participants

Reaction Conditions

Reaction Steps

Hydrogen chloride (2 mL, 0.20 mmol, 2M aq) was added to a solution of tert-butyl 4-(benzylamino)-2-(4-(oxazol-5-yl)phenylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (0.1 g, 0.20 mmol, Example 5a) in MeOH (5 mL) and heated in an open reaction vessel to 76° C. for 1 h. The residual solvent was removed under reduced pressure, the crude product was redissolved in DMSO and purified by preparative HPLC to give N4-benzyl-N2-(4-(oxazol-5-yl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4-diamine (38 mg, 47.5%). MS (ESI+)/(ESI−) m/z 399/397

Provenance & Evidence