Benzylamine → HCID 59333754, compound

Participants

Reaction Steps

Benzylamine (0.030 g, 0.28 mmol) was added to tert-butyl 2-(4-(oxazol-5-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (0.15 g, 0.28 mmol, Example 5b) in dioxane (10 mL) and DMF (0.5 mL). The reaction was stirred at rt over night. The solvent was removed under reduced pressure and the crude product redissolved in EtOAc, washed with saturated NaHCO3 and H2O. The organic layer was dried (MgSO4), filtered and concentrated to give tert-butyl 4-(benzylamino)-2-(4-(oxazol-5-yl)phenylamino)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate (0.120 g, 87%). No further purification.

Provenance & Evidence