Hydrochloric Acid → HCID 46200199, compound

Participants

Reaction Conditions

Reaction Steps

Aniline (0.032 g, 0.34 mmol) was added to a solution of tert-butyl 2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (0.2 g, 0.34 mmol, Example 7a) in DMF (2 mL). The solution was stirred at 70° C. for 1 h. HCl 2M aq (2 ml) was added and the solution heated to 76° C. for 1 h. Solvent was concentrated under reduced pressure and purified on preparative HPLC to give N2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-N4-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (0.060 g, 41.0%). MS (ESI+)/(ESI−) m/z 428/426

Provenance & Evidence