Hydrochloric Acid → HCID 178432897, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-hydroxy-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (2.3 g, 5.44 mmol, Example 9d) was added to a solution of hydrogen chloride (10 mL, 5.44 mmol) in ethanol (20 mL). The solution was stirred at 75° C. for 30 min allowing the EtOH to evaporate. The solution was made basic with potassium carbonate (s) and EtOAc (20 mL) was added. After stirring 10 min the precipitated product was filtered off and dried to give 2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol (1.300 g, 74.1%). MS (ESI+)/(ESI−) m/z 323/321

Provenance & Evidence