反应详情

温度

80 °C

N-Methylcyclohexanamine (9.67 mg, 0.09 mmol) was added to a solution of 6-methyl-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate (40 mg, 0.09 mmol, Example 9a) in DMSO (1 mL) and the reaction was stirred at 80° C. for 2 h. Solvent was allowed to cool down, filtered and the product purified on preparative HPLC to give N4-cyclohexyl-N4,6-dimethyl-N2-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (22.00 mg, 59.7%). MS (ESI+)/(ESI−) m/z 432/430

1. temperatureto cool down
2. filtrationfiltered
3. customthe product purified on preparative HPLC