Water → 6-acetyl-2-[4-(1,3-oxazol-5-yl)anilino]-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-one

Participants

Reaction Steps

1-(4-(Oxazol-5-yl)phenyl)guanidine (2.7 g, 13.35 mmol), methyl 1-acetyl-4-oxopiperidin-3-carboxylate (2.66 g, 13.35 mmol) and sodium ethoxide (0.946 g, 13.35 mmol) in ethanol (15 mL) were heated in a microwave reactor at 100° C. for 15 minutes. The reaction mixture was allowed to reach room temperature and water was added. The solid obtained was filtered, washed with water and dried in a vaccum oven yielding 1-(4-hydroxy-2-(4-(oxazol-5-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (2.90 g, 61.8%).

Provenance & Evidence