(S)-(+)-Tetrahydrofurfurylamine → HCID 59333732, compound

Participants

Reaction Steps

6-Acetyl-2-(4-(oxazol-5-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl trifluoromethanesulfonate (35 mg, 0.07 mmol, Example 26a) in DMSO (1 mL) was dispensed in a library plate. (S)-(tetrahydrofuran-2-yl)methanamine (7.08 mg, 0.07 mmol) was added to the plate and it was left to shake overnight at 80° C., filtered and purified by preparative HPLC to give (S)-1-(2-(4-(oxazol-5-yl)phenylamino)-4-((tetrahydrofuran-2-yl)methylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)ethanone (12.7 mg, 40.4%).

Provenance & Evidence