Nitric Acid → HCID 178432900, Verbindung

Beteiligte Stoffe

Reaktionsschritte

4-(2-Methylimidazol-1-yl)phenylamine (10 g, 57.73 mmol) was dissolved in ethanol (100 mL). Nitric acid (3.96 mL, 57.73 mmol) was carefully added followed by cyanamide (2.427 g, 57.73 mmol). The reaction mixture was heated to reflux overnight. Extra cyanamide (1.942 g, 46.19 mmol) and nitric acid (2.98 mL, 46.19 mmol) were added and then the reaction mixture was refluxed for 16 hours. The reaction mixture was allowed to reach room temperature and ethyl ether (100 mL) was added. The mixture was refrigerated for 2 h and the solid obtained was filtered off and washed with ethyl ether yielding 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (9.40 g, 76%).

Herkunft & Nachweise