tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 59333808, compound

HRID 1930613Notes

Reaction equation

HRID 1930613 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:23][C:24](Cl)=[O:25])[CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH2:23][C:24]([CH:7]2[C:2](=[O:1])[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6]2)=[O:25])[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 27332463-Methoxyphenylacetyl chloride

Product 1

HCID 59333808HCID 59333808, compoundYield 66%

Procedure

tert-Butyl 3-(2-(3-methoxyphenyl)acetyl)-4-oxopiperidine-1-carboxylate (388 mg, 66%) was synthesised from tert-butyl 4-oxopiperidine-1-carboxylate and 2-(3-methoxy-phenyl)acetyl chloride according to the general procedure for the preparation of diketones.

Sources & evidence

ORD record
ord-d2637f9529f5418e8e7ef7fa81c84ca3
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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