Formaldehyde → HCID 46199109, compound

HRID 1930615Notes

Reaction equation

HRID 1930615 reaction equation
[CH:1]1([CH2:6][C:7]2[C:8]3[CH2:29][NH:28][CH2:27][CH2:26][C:9]=3[N:10]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH:24]=[CH:23][N:22]=[C:21]4[CH3:25])=[CH:16][CH:15]=3)[N:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:30]=O>>[CH:1]1([CH2:6][C:7]2[C:8]3[CH2:29][N:28]([CH3:30])[CH2:27][CH2:26][C:9]=3[N:10]=[C:11]([NH:13][C:14]3[CH:15]=[CH:16][C:17]([N:20]4[CH:24]=[CH:23][N:22]=[C:21]4[CH3:25])=[CH:18][CH:19]=3)[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 59333758HCID 59333758, compound

Product 1

HCID 46199109HCID 46199109, compoundYield 6%

Procedure

4-(Cyclopentylmethyl)-6-methyl-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (5.7 mg, 6%) was synthesised from 4-(cyclopentylmethyl)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine and formaldehyde according to the general procedure for reductive amination. MS (ES+) m/z 403.4 (M+H)+

Sources & evidence

ORD record
ord-f582cac112bb4475b3bff1443bdbf12c
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

Loading…