HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylate → tert-Butyl 4-(cyclopentylmethyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylate | HCID 59333704 | — |
| Reactant | HCID 178432900 | HCID 178432900 | — |
| Product | tert-Butyl 4-(cyclopentylmethyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate | HCID 59333795 | 39% |
Reaction Steps
tert-Butyl 4-(cyclopentylmethyl)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (199 mg, 39%) was synthesised from tert-butyl 3-(2-cyclopentylacetyl)-4-oxopiperidine-1-carboxylate and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for the synthesis of pyrimidines. MS (ES+) m/z 489.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08188101B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-746cdae6150d4368835a9d397fc023f7 |
| Source note | uspto-grants-2012_05 |