HCID 59333734, compound → HCID 59333791, compound

HRID 1930624Notes

Reaction equation

HRID 1930624 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH:3]1[C:15](=O)[CH2:16][CH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.[CH3:24][C:25]1[N:26]([C:30]2[CH:35]=[CH:34][C:33]([NH:36][C:37]([NH2:39])=[NH:38])=[CH:32][CH:31]=2)[CH:27]=[CH:28][N:29]=1>>[CH3:24][C:25]1[N:26]([C:30]2[CH:31]=[CH:32][C:33]([NH:36][C:37]3[N:38]=[C:15]([CH2:16][CH:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)[C:3]4[CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7][C:2]=4[N:39]=3)=[CH:34][CH:35]=2)[CH:27]=[CH:28][N:29]=1

Participants

3

Reactant 2

HCID 59333734HCID 59333734, compoundHCID 178432900HCID 178432900, compound

Product 1

HCID 59333791HCID 59333791, compoundYield 86%

Procedure

tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-4-((tetrahydro-2H-pyran-4-yl)methyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (745 mg, 86%) was synthesised from tert-butyl 4-oxo-3-(2-(tetrahydro-2H-pyran-4-yl)acetyl)piperidine-1-carboxylate and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for the synthesis of pyrimidines. MS (ES−) m/z 503.3 (M−H)−

Sources & evidence

ORD record
ord-c0cd0669b2f9426286f1c69b55b0c9e3
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

Loading…