HCID 59333756, compound → HCID 59333771, compound

HRID 1930631Notes

Reaction equation

HRID 1930631 reaction equation
[CH3:1][O:2][CH:3]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:4]([CH:6]1[C:11](=O)[CH2:10][CH2:9][S:8][CH2:7]1)=O.[CH3:19][C:20]1[N:21]([C:25]2[CH:30]=[CH:29][C:28]([NH:31][C:32]([NH2:34])=[NH:33])=[CH:27][CH:26]=2)[CH:22]=[CH:23][N:24]=1>>[CH3:1][O:2][CH:3]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:4]1[C:6]2[CH2:7][S:8][CH2:9][CH2:10][C:11]=2[N:34]=[C:32]([NH:31][C:28]2[CH:29]=[CH:30][C:25]([N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH3:19])=[CH:26][CH:27]=2)[N:33]=1

Participants

3

Reactant 2

HCID 59333756HCID 59333756, compoundHCID 178432900HCID 178432900, compound

Product 1

HCID 59333771HCID 59333771, compoundYield 11%

Procedure

4-(Methoxy(phenyl)methyl)-N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (31.5 mg, 11%) was synthesised from 3-(2-methoxy-2-phenylacetyl)dihydro-2H-thiopyran-4(3H)-one and 1-(4-(2-methyl-1H-imidazol-1-yl)phenyl)guanidine (Example 41c) according to the general procedure for the synthesis of pyrimidines. MS (ES+) m/z 444.0 (M+H)+

Sources & evidence

ORD record
ord-8b1f78cf8f5f4adc8600bf88f38ef7b9
Source dataset
uspto-grants-2012_05
Patent number
US08188101B2

Reaction notes

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