Hydrochloric Acid → N-(4-(2-Methyl-1H-imidazol-1-yl)phenyl)-4-(1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine

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Reaction Conditions

Reaction Steps

tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-4-(1-phenylethyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (612 mg, 1.20 mmol) was dissolved in methanol (10 mL). Hydrochloric acid (0.098 mL, 1.20 mmol) was added and the reaction mixture was stirred at 75° C. for 1 h. The solvent was evaporated under reduced pressure and the crude N-(4-(2-methyl-1H-imidazol-1-yl)phenyl)-4-(1-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine (490 mg, 100%) was used as such in the subsequent step. MS (ES+) m/z 411 (M+H)+

Provenance & Evidence