Hydrochloric Acid → 2-(Benzyl(2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)ethanol

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-(benzyl(2-hydroxyethyl)amino)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (121 mg, 0.22 mmol) was dissolved methanol (2 mL). Hydrochloric acid (0.018 mL, 0.22 mmol) was added and the reaction was stirred at 75° C. for 1 h. The solvent was evaporated under reduced pressure and the crude 2-(benzyl(2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)amino)ethanol (95 mg, 96%) was used as such in the subsequent step. MS (ES+) m/z 456.3 (M+H)+

Provenance & Evidence