N-Ethyltetrahydrofurfurylamine → tert-Butyl 4-(ethyl((tetrahydrofuran-2-yl)methyl)amino)-2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 2-(4-(2-methyl-1H- imidazol-1-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (250 mg, 0.45 mmol, example 69c) was dissolved in DMF (2 mL). N-((tetrahydrofuran-2-yl)methyl)ethanamine (58.2 mg, 0.45 mmol) was added and the reaction mixture was stirred at 85° C. overnight. The reaction was allowed to reach room temperature, the solvent was evaporated under reduced pressure and the crude was used as such in the subsequent step. MS (ES+) m/z 534.4 (M+H)+

Provenance & Evidence